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Phase I–II Clinical Trials

Hexarelin

Growth Hormone ResearchGhrelin SignalingPituitary ResearchEndocrine Research

From

$30.00

Vendors

7

Lab tested

2 COAs

Key benefits

  • Potent GH release
  • Studied for heart protection
  • Stronger with GHRH

Hexarelin (examorelin) is a synthetic hexapeptide in the growth hormone releasing peptide (GHRP) family, studied for growth hormone release through ghrelin receptor activation.

Compare research vendor listings by vial size, price per mg and batch COAs on Peptide Grading.

Regulatory activity

Phase I–II Clinical Trials

Early-stage human trials

Route

Subcutaneous

Often studied away from meals; timing varies by protocol.

Cycle

8-16 weeks Typical duration

Storage

Keep cool and dry; refrigerate reconstituted material at 2–8°C.

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Marketplace

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What the research reports

Research Benefits of Hexarelin

What published research has reported so far. These are research findings, not promised results, and most come from settings very different from research-grade use.

01

Potent GH release

02

Studied for heart protection

03

Stronger with GHRH

What the evidence shows

Hexarelin was studied in humans in the 1990s, mostly in short hormone-response tests. Its GH effect weakens with repeated dosing (tachyphylaxis).

Heart-protection findings come mainly from animal studies and small short human studies.

Studies

Key studies on Hexarelin

1

Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man

Journal of Clinical Endocrinology & Metabolism, 1994. Early human study showing dose-dependent GH release by several routes.

View on PubMed
2

CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart

Circulation Research, 2002. Identified CD36 as the heart receptor through which hexarelin and related peptides act, in animal studies.

View on PubMed

Safety and regulatory position

Not approved · investigational

It is not FDA-approved and is not eligible for routine pharmacy compounding.

It raises cortisol and prolactin as well as GH, and its effect fades with repeated use. Short-term studies report flushing, headache, injection-site reactions and water retention. Raising GH and IGF-1 can reduce insulin sensitivity and raise blood sugar, and long-term effects of keeping IGF-1 elevated, including on cancer risk, are not established. It is prohibited in sport at all times under the WADA list (S2 peptide hormones and growth factors).

Research-grade material sold online is not an approved drug. Its identity, purity and amount can't be assumed without independent testing, so check the vendor's batch COA.

Pairing

How Hexarelin pairs with other compounds

GHRH analog + ghrelin mimetic

GHRH analogs (sermorelin, CJC-1295, tesamorelin) and ghrelin-receptor agonists (ipamorelin, GHRP-2, hexarelin) act on different pituitary receptors, and studies show their GH release adds together. That synergy is the reason they're often paired, but no trial has tested the long-term safety of combining them.

Another drug from the same group

Two GHRH analogs, or two ghrelin mimetics, compete for the same receptor. Stacking them adds side effects without clear extra effect.

Diabetes medicines

Higher GH and IGF-1 levels reduce insulin sensitivity, so hexarelin can raise blood sugar and change how well diabetes medicines work.

Glucocorticoids

Raising GH can speed up cortisol clearance. People on steroid replacement for adrenal insufficiency may need their dose reviewed.

FAQ

Frequently asked questions.

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