Peptide Grading
United StatesAssociation of Human Whole Blood NAD(+) Contents With Aging.
Blood NAD+ declines with aging in males but not females, with significant decline in 40-49 age group.
NAD+
NAD+ is a fundamental coenzyme present in all living cells that serves as a critical electron carrier in metabolic reactions and a substrate for enzymes including sirtuins, PARPs, and CD38. NAD+ levels decline approximately 50% between ages 40 and 60. While not a peptide, NAD+ and its precursors (NMN, NR) are frequently discussed in peptide communities. IV NAD+ infusions are popular at anti-aging clinics, though large-scale human efficacy trials are limited.
Anti-Aging / TelomereAnti-Aging & LongevityMetabolic Health
- Vendors
- 16 vendors
- Sizes
- 100 mg – 1000 mg
- Intake
- Injections · Oral
Typical dose
100-1000mg 1-3x weekly
Daily for 3-5 days
Route
Intravenous
IV infusions are administered slowly over 2-4 hours (rapid infusion causes chest tightness and nausea). Subcutaneous injections can be given at any time. Oral NMN/NR is typically taken in the morning to align with circadian NAD+ rhythms.
Cycle
4-12 weeks Typical duration
Typical duration
Storage
2–6°C2-8°C Refrigerated
Follow vendor guidance
Marketplace
Vendor listings
16 offers for NAD+
| Vendor | Price | Rating | Shipping | COA | Action |
|---|---|---|---|---|---|
Renova Peptides
| $39.00 $0.08/mg | No reviews | 3–5 days United States | None | |
Reta One Labs
| $46.00 $0.09/mg | No reviews | 2 days United States | None | |
Crownwell Research
| $55.00 $0.11/mg | No reviews | 1-5 days United States | None | |
Trulab Peptides
| $55.00 $0.11/mg | No reviews | 2–5 days Worldwide | None | |
Peptix USA
| $57.99 $76.00 $0.58/mg −23.7% | No reviews | 3–5 days United States | None | |
prpeps
| $60.00 $0.12/mg | No reviews | 2 days United States | None | |
Synthesis Peptides
| $63.99 $0.13/mg | No reviews | 2–5 days United States | None | |
Amino Club
| $69.99 $0.14/mg | No reviews | 1–4 days United States | None |
What the research reports
Reported research benefits.
Outcomes described across the published literature and ongoing study, not promised results. Read each as research context, not a personal guarantee.
01
Cellular energy production
02
DNA repair support
03
Anti-aging potential
04
Metabolic regulation
Dosage and protocol
How it is typically studied.
NAD+ is an essential coenzyme involved in cellular energy metabolism, DNA repair, and sirtuin activation. Supplementation protocols include IV infusion (250-1000mg), subcutaneous injection (50-200mg), and oral precursors (NMN 250-1000mg or NR 300-600mg daily). IV NAD+ has gained popularity in wellness and longevity clinics.
01 Route
Intravenous, Subcutaneous, Intramuscular, Oral (precursors)
02 Example range
500mg IV
03 Frequency
Daily for 3-5 days
04 Timing
IV infusions are administered slowly over 2-4 hours (rapid infusion causes chest tightness and nausea). Subcutaneous injections can be given at any time. Oral NMN/NR is typically taken in the morning to align with circadian NAD+ rhythms.
Educational reference only. Use clinician guidance for dosing decisions.
Evidence
What the studies actually show.
Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho.
GDF15, GDF11, AGEs, NLRP3, and sirtuin 1 levels vary with age and sex as potential aging biomarkers.
Peritransplant Energy Changes and Their Correlation to Outcome After Human Liver Transplantation.
Peritransplant energy adenine nucleotide ratios correlate with graft function after liver transplantation.
Microglial mitophagy integrates the microbiota-gut-brain axis to restrain neuroinflammation during neurotropic herpesvirus infection.
Gut microbial metabolite nicotinamide n-oxide suppresses herpes simplex encephalitis via NAD-dependent mitophagy.
Interactions
How it pairs with other peptides.
MOTS-C Synergistic · Emerging
Synergistic for mitochondrial function. Both target cellular energy pathways through complementary mechanisms.
FAQ
Frequently asked questions.
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme critical for cellular energy production, DNA repair, and longevity pathways. Injectable forms are available from peptide vendors, bypassing oral bioavailability limitations.