Pep Grading
United StatesAnecdotal
No published clinical studies were found for MOTS-C. Evidence is limited to preclinical research or community reports.
MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene (MT-RNR1). Discovered in 2015 by Lee et al. at USC, it acts as a metabolic regulator primarily through AMPK activation. In mouse models, MOTS-c prevents diet-induced obesity and insulin resistance, enhances exercise capacity (old mice ran 2x longer on treadmill tests), and reduces age-related metabolic decline. A modified analog (CB4211) showed good tolerability in a Phase 1 human trial. No clinical trials of native MOTS-c in humans have been completed.
Metabolic / MitochondrialMitochondrial TargetingMetabolic HealthAnti-Aging
- Vendors
- 20 vendors
- Sizes
- 10 mg – 40 mg
- Intake
- Injections
Typical dose
5-15mg 1x daily or 3x weekly
2-3 times per week
Route
Subcutaneous
Often administered in the morning. Some protocols suggest dosing before exercise.
Cycle
4-12 weeks Typical duration
Typical duration
Storage
2-8°C Refrigerated
Follow vendor guidance
Marketplace
Vendor listings
20 offers for MOTS-c
| Vendor | Price | Rating | Shipping | COA | Action |
|---|---|---|---|---|---|
Renova Peptides
| $28.00 $2.80/mg | No reviews | 3–5 days United States | None | |
Reta One Labs
| $29.00 $2.90/mg | No reviews | 2 days United States | None | |
Biologix Labs
| $34.01 $42.99 $3.40/mg −20.9% | No reviews | 2 Days United States, Canada | None | |
idunpeptides
| $34.99 $3.50/mg | No reviews | 3–7 days United States, United Kingdom +1 | None | |
Giga Compounds
| $36.00 $40.00 $3.60/mg −10% | No reviews | 2 days United States | None | |
Amino Club
| $39.99 $4.00/mg | No reviews | 1–4 days United States | None | |
HLX LABS
| $39.99 $4.00/mg | No reviews | 2–5 days United States | None | |
primepepsolutions
| $39.99 $4.00/mg | No reviews | 1–3 days Worldwide | None |
What the research reports
Reported research benefits.
Outcomes described across the published literature and ongoing study, not promised results. Read each as research context, not a personal guarantee.
01
Exercise mimetic effects
02
Metabolic health
03
Mitochondrial function
04
Anti-aging
Dosage and protocol
How it is typically studied.
MOTS-c is a mitochondrial-derived peptide researched for metabolic regulation and exercise mimetic effects. Typical doses range from 5-10mg, 2-3 times per week.
01 Route
Subcutaneous
02 Example range
5-10mg
03 Frequency
2-3 times per week
04 Timing
Often administered in the morning. Some protocols suggest dosing before exercise.
Educational reference only. Use clinician guidance for dosing decisions.
Evidence
What the studies actually show.
Interactions
How it pairs with other peptides.
MOTS-c + TB-500
Often discussed together in recovery-focused research stacks.
MOTS-c + GHK-Cu
Sometimes paired in tissue and skin research conversations.
FAQ
Frequently asked questions.
MOTS-c is a mitochondrial-derived peptide researched as an 'exercise mimetic' for its potential effects on metabolism, insulin sensitivity, and cellular energy.