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Animal/Preclinical Only

FOXO4-DRI

Senolytic ResearchCellular Ageingp53 Pathway

From

$137.60

Vendors

7

Lab tested

2 COAs

Key benefits

  • Cleared senescent cells in mouse studies
  • Improved fitness and fur in aged mice
  • Designed to resist breakdown in the body
FOXO4-DRI is a modified peptide built from D-amino acids in reverse order (a 'D-retro-inverso' design). It blocks the binding of the FOXO4 protein to p53, which is studied as a way to make senescent ('zombie') cells self-destruct.

Regulatory activity

Animal/Preclinical Only

Animal studies only

Route

Vial

2 mg, 5 mg, 10 mg listed

Cycle

Varies by study

Typical duration

Storage

-20°C lyophilized · 2–8°C once reconstituted

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What the research reports

Research Benefits of FOXO4-DRI

What published research has reported so far. These are research findings, not promised results.

01

Cleared senescent cells in mouse studies

02

Improved fitness and fur in aged mice

03

Designed to resist breakdown in the body

What the evidence shows

FOXO4-DRI became known from a 2017 mouse study in which it removed senescent cells and improved signs of ageing such as fitness, fur and kidney function. Research since then has stayed in cells and animals. It has not been tested in published human trials.

Safety and regulatory position

Not approved · animal data only

FOXO4-DRI is not approved as a medicine and has no human safety data. Because it acts on the p53 cell-death pathway, its effects on healthy cells in people are unknown. Vendors sell it for laboratory research use only.

FAQ

Frequently asked questions.

A senolytic is a substance that selectively removes senescent cells, old cells that have stopped dividing but linger and release inflammatory signals.