Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from adrenocorticotropic hormone (ACTH) fragment 4-10, with an added Pro-Gly-Pro sequence for metabolic stability. Molecular weight is approximately 813.88 g/mol (formula C37H51N9O10S). Discovered in Russia during the 1980s as part of government-funded neuropeptide research, it is approved in Russia and Ukraine for the treatment of ischemic stroke, cognitive disorders, encephalopathy, and optic nerve atrophy. Despite its ACTH origin, Semax does not activate adrenal corticosteroid production, acting selectively on brain-specific pathways.
Typical dose
300-1000mcg 1-3 times daily
1-2 times daily
Route
Intranasal spray
Best used in the morning or early afternoon. Effects typically felt within 15-30 minutes of intranasal administration.
Cycle
2-4 weeks on, 1-2 weeks off Typical duration
Typical duration
Storage
2-8°C Refrigerated
Follow vendor guidance
Marketplace
17 offers for Semax
| Vendor | Price | Rating | Shipping | COA | Action |
|---|---|---|---|---|---|
Biologix Labs
| $24.98 $31.99 $5.00/mg −21.9% | No reviews | 2 Days United States, Canada | None | |
idunpeptides
| $24.99 $2.50/mg | No reviews | 3–7 days United States, United Kingdom +1 | None | |
Reta One Labs
| $26.00 $2.60/mg | No reviews | 2 days United States | None | |
Amino Club
| $29.95 $3.00/mg | No reviews | 1–4 days United States | None | |
Certa Peptides
| $29.99 $6.00/mg | No reviews | 1–4 days Switzerland, United Kingdom +29 | None | |
Bionova Peptides
| $30.00 $60.00 $3.00/mg −50% | No reviews | 1–3 days United States | None | |
Trulab Peptides
| $32.00 $6.40/mg | No reviews | 2–5 days Worldwide | None | |
HLX LABS
| $35.00 $44.99 $3.50/mg −22.2% | No reviews | 2–5 days United States | None |
What the research reports
Outcomes described across the published literature and ongoing study, not promised results. Read each as research context, not a personal guarantee.
Cognitive enhancement
Neuroprotection
Memory improvement
Focus
Dosage and protocol
Semax is a nootropic peptide typically administered intranasally at 200-600mcg per day. Developed in Russia for cognitive enhancement and stroke recovery. Effects typically felt within 15-30 minutes
01 Route
Intranasal spray, Subcutaneous
02 Example range
200-300mcg
03 Frequency
1-2 times daily
04 Timing
Best used in the morning or early afternoon. Effects typically felt within 15-30 minutes of intranasal administration.
Educational reference only. Use clinician guidance for dosing decisions.
Evidence
Complex neurostimulation with Semax achieved 83-94% efficacy in improving visual field and light sensitivity in vascular optic neuropathy.
Selank and Semax produce distinct functional connectivity changes in amygdala and prefrontal regions.
Semax increased default mode network volume in medial frontal cortex compared to placebo on fMRI.
LDL-C reduction benefit diminishes below 90 mg/dl; NNT increases sharply as baseline LDL-C declines.
Interactions
SELANK Neutral · Well-documented
Neutral to mildly synergistic. Different neurological targets with no known negative interaction.
FAQ
Semax is a synthetic peptide based on ACTH (adrenocorticotropic hormone) fragment, developed in Russia and extensively researched for cognitive enhancement and neuroprotection.
Pep Grading
United States
Romania