Peptide Grading
Research peptide
MOTS-c
From
$28.00
Vendors
23
Lab tested
6 COAs
Key benefits
- Better insulin sensitivity in mice
- Improved exercise capacity in mice
- Encoded in mitochondrial DNA
- Natural levels rise with exercise
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame in the mitochondrial 12S rRNA region.
Peptide Grading tracks MOTS-c vendors, quantities, prices, shipping details, and COA information to make research-product listings easier to compare.
Typical dose
5-15mg 1x daily or 3x weekly
2-3 times per week
Route
Subcutaneous
Often administered in the morning. Some protocols suggest dosing before exercise.
Cycle
4-12 weeks Typical duration
Storage
2-8°C Refrigerated
Follow vendor guidance
Marketplace
Compare all MOTS-c vendors
Prices per size, coupon codes, lab reports and shipping.
| Vendor | Price | Coupon | Lab test | Shipping | |
|---|---|---|---|---|---|
Renova Peptides 10 mg | $28.00 Lowest price$2.80/mg | No code | Not on file | 3–5 days
| Buy |
Reta One Labs 10 mg | $29.00 $2.90/mg | Not on file | 2 days
| Buy | |
 PepVida Labs 10 mg | $29.99$49.00 −38.8%$3.00/mg | Not on file | 1-3 days
| Buy | |
Biologix Labs 10 mg | $34.01$42.99 −20.9%$3.40/mg | Not on file | 2 Days
| Buy | |
idunpeptides 10 mg | $34.99 $3.50/mg | Not on file | 3–7 days
| Buy | |
Giga Compounds 10 mg | $36.00$40.00 −10%$3.60/mg | Not on file | 2 days
| Buy | |
Amino Club 10 mg | $39.99 $4.00/mg | Not on file | 1–4 days
| Buy | |
 Genesis Biomapping 10 mg | $39.99 $4.00/mg | Not on file | 3 days
| Buy |
United States- No codeBuy
What the evidence shows
MOTS-c was discovered in 2015, and most research is in cells and mice. Human studies so far measure natural MOTS-c levels; they don't test it as a treatment.
A modified analog (CB4211) reached a small early-stage human trial, but its results don't apply directly to MOTS-c itself.
Safety and regulatory position
Not approved · preclinicalMOTS-c is not an approved drug. In April 2026 FDA removed it from its list of substances with safety concerns for compounding (Category 2), and an advisory committee reviewed it in July 2026, but no rule allowing pharmacies to compound it has been issued.
There is no published human safety data for injected MOTS-c. Research-grade material sold online is not an approved drug. Its identity, purity and amount can't be assumed without independent testing, so check the vendor's batch COA.
FAQ
Frequently asked questions.
Mitochondrial peptide that activates AMPK pathway and may improve glucose metabolism and exercise capacity.