Ipamorelin is the most selective growth hormone secretagogue (GHS) available, a synthetic pentapeptide (MW ~711.86 g/mol, formula C38H49N9O5) that stimulates pulsatile GH release from the pituitary gland without significantly affecting cortisol, prolactin, or appetite. It is widely regarded as the mildest GHS, making it popular in anti-aging, body composition, and recovery contexts. However, research on ipamorelin is limited, and it is not FDA-approved for any indication.
Typical dose
200-300mcg
2-3 times daily
Route
Subcutaneous
Best administered on empty stomach, at least 30 minutes before food. Common times: morning upon waking, pre-workout, and/or before bed.
Cycle
3-6 months
Typical duration
Storage
2-8°C
Follow vendor guidance
Marketplace
16 offers for Ipamorelin
| Vendor | Price | Rating | Shipping | COA | Action |
|---|---|---|---|---|---|
Biologix Labs
| $17.99 $21.99 $8.99/mg −18.2% | No reviews | 2 Days United States, Canada | None | |
Bionova Peptides
| $20.00 $39.99 $4.00/mg −50% | No reviews | 1–3 days United States | 1 file | |
Certa Peptides
| $23.99 $11.99/mg | No reviews | 1–4 days Switzerland, United Kingdom +29 | 1 file | |
idunpeptides
| $29.99 $3.00/mg | No reviews | 3–7 days United States, United Kingdom +1 | 1 file | |
Amino Club
| $32.49 $49.99 $3.25/mg −35% | No reviews | 1–4 days United States | 1 file | |
HLX LABS
| $34.99 $39.99 $7.00/mg −12.5% | No reviews | 2–5 days United States | 1 file | |
American Peptides
| $40.00 $8.00/mg | No reviews | 1-2 days United States | 2 files | |
bioinfinity
| $45.00 $9.00/mg | No reviews | 3–5 days United States, Puerto Rico | 1 file |
What the research reports
Outcomes described across the published literature and ongoing study, not promised results. Read each as research context, not a personal guarantee.
Clean GH release
Minimal side effects
Anti-aging research
Sleep quality
Recovery
Dosage and protocol
Ipamorelin is a selective growth hormone secretagogue typically dosed at 100-300mcg per injection, 1-3 times daily. It's often combined with CJC-1295 for enhanced GH release. Half-life: ~2 hours.
01 Route
Subcutaneous
02 Example range
200-300mcg
03 Frequency
2-3 times daily
04 Timing
Best administered on empty stomach, at least 30 minutes before food. Common times: morning upon waking, pre-workout, and/or before bed.
Educational reference only. Use clinician guidance for dosing decisions.
Evidence
Ipamorelin was well-tolerated but showed no significant difference vs placebo for postoperative ileus.
Ipamorelin shows dose-proportional pharmacokinetics with 2-hour half-life and potent GH stimulation.
GHRPs and metabolites detected in urine with varying detection windows after nasal administration.
High-throughput LC-MS/MS screen with peptide derivatization detected 8 GHRPs in rat urine after IV administration.
STZ diabetic mice show GH hypersecretion and GH resistance similar to type 1 diabetes in humans.
Interactions
CJC-1295 Synergistic · Well-documented
Synergistic for GH release. CJC-1295 (GHRH analog) plus Ipamorelin (ghrelin mimetic) amplifies GH pulse through dual-pathway stimulation.
BPC-157 Neutral · Emerging
No known negative interaction. Commonly used together in clinical settings. Different primary targets.
FAQ
Ipamorelin is one of the most selective and cleanest growth hormone-releasing peptides, producing GH release without significant effects on cortisol or prolactin. It's widely available through compounding pharmacies.
Pep Grading
United States
Romania